Advantages of adding a course of tetracycline to single dose ampicillin and probenecid in the treatment of gonorrhoea.

نویسندگان

  • G L Ridgway
  • J D Oriel
چکیده

Chlamydia trachomatis was reisolated from 11 of 12 men with gonorrhoea who had initially yielded chlamydiae and who had been treated with ampicillin and probenecid (AMP) only, but from none of five such men treated with ampicillin and probenecid followed by tetracycline (AMPT). These results correlated with the absence of postgonococcal urethritis (PGU) in the group treated with AMPT. C trachomatis was isolated or reisolated from 20 of 25 women after treatment with AMP, compared with none of 14 women treated with AMPT. We recommend the addition of a course of tetracycline to the routine single dose treatment for gonorrhoea in men and women.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Single oral dose of 1-5g. talampicillin in the treatment of gonorrhoea.

81 patients have been treated with single oral doses of 1-5 g. (6 tablets) of talampicillin without probenecid. The failure rate amongst those followed was only 4-2 per cent. No side-effects were reported. These results were superior to those obtained with 2-0g. or equivalent of ampicillin, amoxycillin, or pivampicillin with probenecid. Talampicillin is thus the most potent ampicillin-like anti...

متن کامل

Oral cefuroxime axetil compared with oral ampicillin in treating acute uncomplicated gonorrhoea.

The efficacy and tolerance of single oral doses of cefuroxime axetil (1.5 g) were compared with oral ampicillin (3 g) for treating acute gonococcal urethritis in 110 men and 30 women. Each dose was given with 1 g probenecid. Of the 62 assessable patients who received ampicillin, two failed to respond to treatment. Of 67 assessable patients who received cefuroxime axetil, one failed to respond. ...

متن کامل

Single-dose oral ampicillin in the treatment of gonococcal urethritis in males.

Penicillin and its analogues have been, and still are, the drugs of choice in the treatment of gonorrhoea in most parts of the world. The United States Centre for Disease Control recommends, as first line single-dose treatment, the use of either aqueous procaine penicillin G (4.8 mega-units intramuscularly as a single-dose with oral probenecid 1 g by mouth) or ampicillin 3.5 g (or amoxycillin 3...

متن کامل

Pivampicillin hydrochloride in uncomplicated gonorrhoea.

Because of the inconvenience of injections and the serious anaphylactic reactions sometimes seen in connection with parenteral penicillin treatment, oral ampicillin has been proposed as an alternative in the treatment of gonorrhoea. Extensive studies have shown that the efficacy of ampicillin in a single dose of 2 g. combined with probenecid, or 2 g. divided into two doses with a 5-hour interva...

متن کامل

Comparative trial of single-dose ciprofloxacin and ampicillin plus probenecid for treatment of gonococcal urethritis in men.

In a double-blind comparative trial, 100 men with uncomplicated gonorrhea caused by beta-lactamase-negative Neisseria gonorrhoeae were treated with a single 0.25-g dose of ciprofloxacin administered orally or with 3.5 g of ampicillin plus 1.0 g of probenecid administered orally. Urethral infection was eradicated in all 49 men treated with ciprofloxacin and in 47 (92%) of 51 men treated with amp...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The British journal of venereal diseases

دوره 60 4  شماره 

صفحات  -

تاریخ انتشار 1984